Key result
Myocardial injury occurs in ~16% of hospitalized COVID-19 patients.
Why the study?
The occurrence and frequency of myocardial injury in patients with COVID-19 were not well established.
Meta-Analysis (n=1,229)
Highlights need for cardiac surveillance in COVID-19; supports prevalence estimates while leaving optimal management strategies open.
INTRODUCTION: Cardiac complications of COVID-19 are potentially life-threatening. The occurrence of myocardial injury in the context of COVID-19 is multifactorial and has generated increasing interest. METHODS: A systematic review with a meta-analysis of the literature was performed. MEDLINE and EMBASE were searched. Two independent reviewers evaluated the selected manuscripts for the outcome "myocardial injury", defined by troponin elevation above the 99th percentile. The study heterogeneity and risk of bias were evaluated. RESULTS: Eight studies, with a total of 1,229 patients, were included. The frequency of myocardial injury was 16% (95% CI: 9%-27%). The heterogeneity among the studies was high (93%). CONCLUSIONS: Myocardial injury may occur in patients with COVID-19, with a frequency of 16% according to current studies. Continuous research is needed to update these findings as the pandemic evolves and to define the implications of myocardial injury in the context of this infection.
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Lorenzo et al. (2020) conducted a meta-analysis in COVID-19 (n=1,229). COVID-19 was evaluated on Myocardial injury (troponin elevation above the 99th percentile) (95% CI 9-27). In patients with COVID-19, the pooled frequency of myocardial injury was 16% (95% CI: 9-27%).
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