Key result
A new silicone-coated oxygenator reduces hemolysis while matching conventional gas exchange during CPB in goats.
Why the study?
Does a silicone-coated membrane oxygenator improve gas exchange and reduce hemolysis compared to a conventional oxygenator in a goat model of cardiopulmonary bypass?
Does a silicone-coated membrane oxygenator improve gas exchange and reduce hemolysis compared to a conventional oxygenator in a goat model of cardiopulmonary bypass?
Answers are grounded in this paper and cite their sources.
A novel silicone-coated membrane oxygenator demonstrated comparable gas exchange and reduced hemolysis compared to a conventional oxygenator in a preclinical goat model, suggesting suitability for long-term cardiac support.
The surface of polypropylene hollow fiber was successfully coated with a very thin (0.2 micron) silicone layer. Experimental studies were performed in long-term (6 h) normothermic cardiopulmonary bypass (CPB) using 10 goats. A conventional membrane oxygenator (Mera Excelung HPO-15H, MERA, Tokyo, Japan) was used for 5 goats as a control (Group C) and a new silicone-coated membrane oxygenator, which is of the same construction as that of the one used for Group C, for 5 (Group S). The O2 transfer and CO2 removal functions showed the same ranges. In the other parameters, there were no differences between the 2 groups. As for hemolysis, however, the plasma free hemoglobin of Group S was lower than that of Group C. Currently, 3 chronic percutaneous cardiopulmonary support (PCPS) experimental models have been conducted, and there has been no evidence of thromboembolism or deterioration of the oxygenator. In conclusion, this new oxygenator is suitable not only for CPB, but also for long-term cardiac support.
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Iida et al. (1997) studied Cardiopulmonary bypass (n=10). Silicone-coated membrane oxygenator vs. Conventional membrane oxygenator was evaluated on O2 transfer, CO2 removal, and hemolysis. A new silicone-coated membrane oxygenator showed similar gas exchange but lower plasma free hemoglobin compared to a conventional oxygenator during 6-hour cardiopulmonary bypass in goats.
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