Key result
Simulated Na/Ca exchange reduction during ischemia enhances calcium oscillations, suggesting blockade may not be therapeutic.
Why the study?
Does blocking Na/Ca exchange activity reduce calcium oscillations during ischemia?
Population
Computational simulation model of intracellular sodium rise during ischemia
Comparison
Alteration of Na/Ca exchange activity vs Baseline Na/Ca exchange activity
Design
Preclinical
Authors
Loading...
May caution against Na/Ca exchange blockade in ischemia; leaves open its net effect on arrhythmias pending in vivo studies.
Does blocking Na/Ca exchange activity reduce calcium oscillations during ischemia?
Simulation data suggest that blocking Na/Ca exchange may paradoxically enhance calcium oscillations, implying it may not be therapeutic for acute ischemic arrhythmias.
Denis Noble (2002) studied Ischemia. Na/Ca exchange activity was evaluated on Calcium oscillations and intracellular calcium levels. Simulation of sodium-calcium exchange activity during ischemia suggests that reducing its activity enhances calcium oscillations, implying that blocking Na/Ca exchange may not be therapeutic.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: