Key result
Selective Na/H exchange inhibitors, such as cariporide and KB-R9032, significantly suppressed coronary ischemia and reperfusion-induced ventricular fibrillation in canine models.
Why the study?
Do Na-H exchange subtype 1 inhibitors or Na/Ca exchange inhibitors prevent arrhythmias in canine models of myocardial ischemia and reperfusion?
Population
Canine models of coronary ischemia and reperfusion induced arrhythmias, as well as digitalis or adrenaline…
Design
Preclinical
Authors
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Hypothesis-generating for NHE-1 inhibition in ischemia-reperfusion arrhythmias; should not yet change clinical practice.
Do Na-H exchange subtype 1 inhibitors or Na/Ca exchange inhibitors prevent arrhythmias in canine models of myocardial ischemia and reperfusion?
Preclinical evidence suggests that Na-H exchange subtype 1 inhibitors (cariporide and KB-R9032) specifically protect against ischemia/reperfusion-induced arrhythmias in canine models, unlike Na/Ca exchange inhibitors.
Hashimoto et al. (2000) conducted a review in Ischemia and reperfusion induced arrhythmias. Na/H exchange inhibitors (cariporide, KB-R9032) vs. Vehicle/Control was evaluated on Occurrence of ventricular fibrillation (VF). Selective Na/H exchange inhibitors, such as cariporide and KB-R9032, significantly suppressed coronary ischemia and reperfusion-induced ventricular fibrillation in canine models.
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