Key result
KB-R7943, a selective Na+/Ca2+ exchange inhibitor, significantly improved post-ischemic recovery of left ventricular function and dose-dependently reduced the incidence and duration of ventricular fibrillation in rat models of myocardial ischemia/reperfusion injury.
Why the study?
Does KB-R7943 improve post-ischemic functional recovery and reduce reperfusion arrhythmias in animal models of myocardial ischemia/reperfusion injury?
Population
Canine cardiac sarcolemmal and sarcoplasmic reticular vesicles; isolated perfused hearts and anesthetized in…
Comparison
KB-R7943 administered pre-ischemia or… vs Vehicle control, diltiazem, and lidocaine.
Design
Preclinical
Follow-up
30-min reperfusion; 10-min reperfusion
Authors
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KB-R7943 effects in rats should not alter practice; leaves open translation of Na+/Ca2+ exchange inhibition to human ischemia/reperfusion injury.
Does KB-R7943 improve post-ischemic functional recovery and reduce reperfusion arrhythmias in animal models of myocardial ischemia/reperfusion injury?
p-value: p=<0.01
KB-R7943, a selective Na+/Ca2+ exchange inhibitor, demonstrates cardioprotective effects against myocardial ischemia/reperfusion injury and reduces reperfusion arrhythmias in preclinical models.
Nakamura et al. (1998) studied Myocardial ischemia/reperfusion injury. KB-R7943 vs. Control (vehicle), diltiazem, lidocaine was evaluated on Post-ischemic recovery of left ventricular function and incidence/duration of ventricular fibrillation (p=<0.01). KB-R7943, a selective Na+/Ca2+ exchange inhibitor, significantly improved post-ischemic recovery of left ventricular function and dose-dependently reduced the incidence and duration of ventricular fibrillation in rat models of myocardial ischemia/reperfusion injury.
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