Why the study?
Does KB-R7943 reduce ischemia/reperfusion or digitalis arrhythmias in beagle dogs?
Does KB-R7943 reduce ischemia/reperfusion or digitalis arrhythmias in beagle dogs?
Na+/Ca2+ exchange inhibition with KB-R7943 does not suppress ischemia/reperfusion or digitalis arrhythmias in a canine model, suggesting it may not be a useful antiarrhythmic strategy.
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KB-R7943 lacks antiarrhythmic efficacy in canine ischemia/reperfusion; leaves open Na+/Ca2+ exchange inhibition as a therapeutic target in other models.
Miyamoto et al. (2002) studied this question.
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