Why the study?
Does KB-R7943 reduce ischemia/reoxygenation injury in isolated rat cardiomyocytes and hearts?
Population
Isolated rat cardiomyocytes and Langendorff-perfused rat hearts
Comparison
KB-R7943 administered during anoxia vs No KB-R7943 treatment (implied control)
Design
Preclinical
Follow-up
Up to 110 min anoxia and 50 min reoxygenation
Authors
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KB-R7943 protection in rat models should not change practice; leaves open translation of reverse NCX inhibition to clinical ischemia-reperfusion.
Does KB-R7943 reduce ischemia/reoxygenation injury in isolated rat cardiomyocytes and hearts?
Inhibition of the reverse mode of the Na+/Ca2+ exchanger with KB-R7943 protects rat cardiomyocytes from ischemia-reoxygenation injury.
Ladilov et al. (1999) studied this question.
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