Key result
High fat and low muscle mass in type 2 diabetes were synergistically associated with higher baseline HbA1c (P=0.009) and attenuated exercise-induced improvements in cardiometabolic risk factors.
Why the study?
Does baseline body composition (fat and muscle mass) affect cardiometabolic risk factors and their response to 6-month exercise training in patients with type 2 diabetes?
Population
248 participants with type 2 diabetes
Comparison
6-month exercise training vs Comparison based on baseline body composition
Design
Cohort
Follow-up
6 months
Authors
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Patients with sarcopenic obesity may show blunted exercise responses; hypothesis-generating observation warrants targeted RCTs before practice change.
Cohort (n=248)
Does baseline body composition (fat and muscle mass) affect cardiometabolic risk factors and their response to 6-month exercise training in patients with type 2 diabetes?
p-value: p=0.009
In patients with type 2 diabetes, the combination of high fat and low muscle mass is associated with worse baseline glycemic control and blunts the cardiometabolic benefits of exercise training.
Terada et al. (2017) conducted a cohort in type 2 diabetes (n=248). High fat and low muscle mass vs. Low fat and/or high muscle mass was evaluated on Cardiometabolic risk factors (HbA1c, visceral adipose tissue, insulin resistance, and triglycerides) (p=0.009). High fat and low muscle mass in type 2 diabetes were synergistically associated with higher baseline HbA1c (P=0.009) and attenuated exercise-induced improvements in cardiometabolic risk factors.
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