Key result
Higher leg fat mass linked to ~18% lower odds of elevated HbA1c per SD.
Why the study?
The study aimed to evaluate the effect of adiposity and fat distribution on the odds of elevated cardiovascular risk factors among adults with type 2 diabetes mellitus.
Does adiposity and fat distribution affect the odds of elevated cardiovascular risk factors in adults with type 2 diabetes mellitus?
Population
2,427 adults with type 2 diabetes mellitus
Comparison
Different indicators of adiposity and fat distribution assessed by DXA
Design
Cross-sectional study
Authors
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Supports considering fat distribution in T2DM risk assessment; leaves open causal roles and need for prospective validation.
Cross-Sectional (n=2,427)
Does adiposity and fat distribution affect the odds of elevated cardiovascular risk factors in adults with type 2 diabetes mellitus?
Odds Ratio: 0.82 (95% CI 0.7–0.96)
In patients with type 2 diabetes, subcutaneous lower body fat is associated with a more favorable glycemic profile, whereas central adiposity correlates with poorer control of cardiovascular risk factors.
Ding et al. (2021) conducted a cross-sectional in type 2 diabetes mellitus (n=2,427). Adiposity and fat distribution was evaluated on Elevated HbA1c (≥7.0%) (OR 0.82, 95% CI 0.70-0.96). Each SD increase in leg fat mass was associated with lower odds of elevated HbA1c (OR 0.82; 95% CI 0.70-0.96), whereas central adiposity was associated with poorer cardiovascular risk factor control.
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