Key result
In T2DM patients, para-perirenal fat thickness was independently associated with triglycerides (β=0.173, p<0.01) and serum creatinine (β=0.218, p<0.01).
Why the study?
Obesity is a global disease leading to cardiovascular and metabolic complications, prompting investigation into the relationship between obesity indicators and metabolic risk factors in type 2 diabetes mellitus.
Cross-Sectional (n=337)
In patients with T2DM, specific obesity indicators such as para-perirenal fat thickness and waist circumference are significantly associated with metabolic risk factors.
Hypothesis-generating in T2DM; prospective studies needed before considering para-perirenal fat as a clinical marker.
Rationale and objectives Obesity, accumulation of adipose tissue, is a global disease that can lead to cardiovascular and metabolic complications. The aim of this study was to investigate the relationship between obesity indicators and metabolic risk factors in type 2 diabetes mellitus (T2DM) patients. Materials and methods A total of 337 T2DM subjects were included in our study. The metabolic risk factors including diabetes duration, fast plasma glucose (FPG), height, weight, systolic blood pressure (SBP), diastolic blood pressure (DBP), estimated average glucose (eAG), glycated hemoglobin (HbA1c), total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-c), low-density lipoprotein-cholesterol (LDL-c), triglyceride (TG), blood urea nitrogen (BUN), serum creatinine (Scr), free fatty acid (FFA), uric acid (UA), cystatin c (cysc), albumin (Alb), urinary albumin creatinine ratio (UACR) were recorded. The obesity indicators included body surface area (BSA), body mass index (BMI), waist circumference (WC), waist-to-hip ratio (WHR), para -perirenal fat thickness (PRFT), total abdominal fat (TAF), subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT). The association between obesity indicators and metabolic risk factors was investigated by univariate and multivariate analysis. Results HDL-c was independently associated with WHR and PRFT (β = −0.126 vs. −0.214, both p < 0.05). TG and Scr were both independently associated with PRFT (β = 0.173 vs. 0.218, both p < 0.01, respectively). UA was independently associated with BSA (β = 0.172, p < 0.01) and PRFT (β = 0.151, p < 0.01). cysc, Alb and UACR were independently associated with WC (β = 0.274 vs. 0.204 vs. 0.182, all p < 0.01). Conclusion In T2DM patients, obesity indicators were significantly associated with metabolic risk factors.
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Xu et al. (2023) conducted a cross-sectional in Type 2 diabetes mellitus (T2DM) (n=337). Obesity indicators (e.g., BMI, waist circumference, para-perirenal fat thickness) was evaluated on Association between obesity indicators and metabolic risk factors. In T2DM patients, para-perirenal fat thickness was independently associated with triglycerides (β=0.173, p<0.01) and serum creatinine (β=0.218, p<0.01).
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