Key result
In patients with type 2 diabetes, abdominal obesity was significantly associated with increased atherosclerosis, indicated by greater carotid intima-media thickness and coronary artery calcification.
Why the study?
Is abdominal obesity associated with increased atherosclerosis and insulin resistance in patients with type 2 diabetes mellitus?
Cross-Sectional (n=530)
Blinded outcome assessment
Yes
Is abdominal obesity associated with increased atherosclerosis and insulin resistance in patients with type 2 diabetes mellitus?
Abdominal obesity is significantly associated with increased atherosclerosis and insulin resistance in Korean patients with type 2 diabetes, even among those with a normal body mass index.
Answers are grounded in this paper and cite their sources.
Supports abdominal obesity evaluation in type 2 diabetes beyond BMI; leaves open causal effects on atherosclerosis.
The aim of this study was to investigate the relationship between obesity, insulin resistance and atherosclerosis in type 2 diabetes mellitus (T2DM) patients. Total 530 patients with T2DM were included. To evaluate the severity of atherosclerosis, we measured the coronary artery calcification (CAC) score, intima-media thickness (IMT) of the common carotid artery, and the ankle-brachial pressure index (ABPI). Subjects were classified according to body mass index (BMI), a marker of general obesity, and waist-to-hip ratio (WHR), a marker of regional obesity. The insulin sensitivity index (ISI) was measured by the short insulin tolerance test. All subjects were classified into four groups, according to BMI: the under-weight group, the normal-weight (NW) group, the over-weight (OW) group, and the obese (OB) group. WHR and systolic blood pressure, triglycerides (TG), HDL-cholesterol (HDLC), free fatty acids (FFA), fibrinogen, and fasting c-peptide levels were significantly different between BMI groups. TG, HDL-C, FFA, fibrinogen and ISI were significantly different between patients with and without abdominal obesity. In the OW group as well as in the NW group, carotid IMT, ABPI and CAC score were significantly different between patients with and without abdominal obesity. This study indicates that abdominal obesity was associated with atherosclerosis in T2DM patients.
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Cho et al. (2008) conducted a cross-sectional in Type 2 Diabetes Mellitus (n=530). Abdominal obesity vs. No abdominal obesity was evaluated on Atherosclerosis markers (carotid intima-media thickness, ankle-brachial pressure index, and coronary artery calcification score). In patients with type 2 diabetes, abdominal obesity was significantly associated with increased atherosclerosis, indicated by greater carotid intima-media thickness and coronary artery calcification.
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