Key result
Adiposity was a strong determinant of pulse wave velocity, while hyperglycemia and insulin resistance correlated with carotid intimal-medial thickness, plaque index, and coronary calcium scores.
Why the study?
What is the relationship between regional patterns of adiposity, insulin resistance, and subclinical atherosclerosis in obese patients with type 2 diabetes?
Population
52 overweight and obese men and women with type 2 diabetes of relatively short known duration
Design
Cross-sectional
Authors
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Suggests separate mechanisms for stiffness versus plaque in obese T2D; hypothesis-generating and should not change practice.
Cross-Sectional (n=52)
What is the relationship between regional patterns of adiposity, insulin resistance, and subclinical atherosclerosis in obese patients with type 2 diabetes?
Obesity may drive early subclinical macrovascular disease via vessel stiffness, while hyperglycemia and insulin resistance contribute to atheroma progression in type 2 diabetes.
Hegazi et al. (2003) conducted a cross-sectional in Type 2 diabetes (n=52). Adiposity and insulin resistance was evaluated on Subclinical atherosclerosis (pulse wave velocity, carotid IMT, plaque index, coronary and aortic calcification). Adiposity was a strong determinant of pulse wave velocity, while hyperglycemia and insulin resistance correlated with carotid intimal-medial thickness, plaque index, and coronary calcium scores.
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