Addition of desoxyribonucleic acid, gelatin, fibrinogen, and especially hyaluronic acid to normal human citrated blood causes a considerable increase in E.S.R. Hyaluronic acid acts only in its highly polymerized form, thus suggesting that molecular weight is an important factor in this reaction, as well as asymmetry of the molecule. Hyaluronidase specifically reverses the action of hyaluronate on E.S.R. Intravenous injection of hyaluron- ate in guinea pig and rabbit leads to increased E.S.R. Intravenous injection of hyaluronidase promptly causes the increased rate to become normal.
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Meyer et al. (1945) studied this question.