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The first catalytic asymmetric addition of arylacetylenes to α‐imino esters was carried out using chiral copper(I) complexes as catalysts under mild reaction conditions, providing the corresponding alkynylation products in good yields with 67–74 % ee values. Profound effects of the ligand‐to‐metal ratio and additives on the stereofacial selection were observed. Both enantiomers of a given product can be obtained with almost identical enantiomeric excess using the same chiral ligand by adjusting the ligand‐to‐metal ratio.
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Shao et al. (2007) studied this question.
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