What question did this study set out to answer?

To determine when and how initial cell-fate distinctions arise in early mammalian development by investigating the role of HMGA1 in two-cell mouse embryos.

October 25, 2021The FASEB Journal

Asymmetric expression of maternal mRNA governs first cell‐fate decision

View Full Paper

Ask AI

Bookmark

Authors

YWYingmei WangTianjin Medical University General Hospital XZXiaoman ZhengSouth China Agricultural University RCRui ChengShanghai University of Sport

Discussion

Member takes

Implication

Experimental study reveals asymmetric HMGA1 distribution directs inner cell mass fate via Sox2 in two-cell mouse embryos, indicating lineage differentiation begins earlier than previously recognized.

Key Points

To determine when and how initial cell-fate distinctions arise in early mammalian development by investigating the role of HMGA1 in two-cell mouse embryos.
Assessed HMGA1 protein distribution across individual blastomeres in early mouse embryos.
Conducted targeted knockdown of Hmga1 expression within one blastomere of two-cell stage embryos.
Monitored the downstream expression of the inner cell mass-specific transcription factor Sox2 and lineage allocation.
HMGA1 distributes unevenly between sister blastomeres as early as the two-cell embryonic stage.
Selective Hmga1 knockdown in one blastomere reduced the lineage contribution of that cell's descendants to the inner cell mass.
HMGA1 promotes the expression of the inner cell mass-specific regulator Sox2, establishing early developmental heterogeneity.

Cite This Study

Wang et al. (2021) studied this question.

synapsesocial.com/papers/6aa118b4b6e053eb128d3f00 https://doi.org/10.1096/fj.202101196r

View Full Paper

Ask AI

Bookmark

Implication

Experimental study reveals asymmetric HMGA1 distribution directs inner cell mass fate via Sox2 in two-cell mouse embryos, indicating lineage differentiation begins earlier than previously recognized.

Asymmetric expression of maternal mRNA governs first cell‐fate decision

Discussion

Member takes

Implication

Key Points

Cite This Study

Asymmetric expression of maternal mRNA governs first cell‐fate decision

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider