What question did this study set out to answer?

To develop and evaluate a semiautomated PET quantification pipeline for estimating F 18 Florbetapir amyloid plaque binding without subject-specific MRI scans, validating its diagnostic accuracy against postmortem neuropathology.

September 3, 2015Journal of Nuclear MedicineOpen Access

A Semiautomated Method for Quantification of F 18 Florbetapir PET Images

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Authors

AJAbhinay D. JoshiMedpace (United States)MPMichael J. PontecorvoEli Lilly (United States)MLMing‐Chi LuTzu Chi University

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Implication

Validation study demonstrates reliable amyloid plaque quantification in postmortem and healthy cohorts, highlighting an accurate MRI-free PET analysis method.

Key Points

To develop and evaluate a semiautomated PET quantification pipeline for estimating F 18 Florbetapir amyloid plaque binding without subject-specific MRI scans, validating its diagnostic accuracy against postmortem neuropathology.
Ten-minute F 18 Florbetapir PET images were spatially normalized to Montreal Neurologic Institute space using a custom template to derive mean cortical standardized uptake value ratios (mcSUVr) against four candidate reference regions.
The method was tested in 74 young cognitively normal individuals (<50 years) and 59 autopsied subjects with neuropathologically confirmed amyloid-beta neuritic plaque burdens.
Whole-cerebellum mcSUVrs demonstrated the strongest correlation with postmortem neuropathologic measures of amyloid burden (r = 0.71–0.75, P < 0.0001).
Using a whole-cerebellum mcSUVr cutoff of 1.10, the pipeline correctly classified 100% (74/74) of young controls (range: 0.87–1.08), 100% (20/20) of autopsy-negative cases, and 97.4% (38/39) of pathology-confirmed amyloid-positive cases.

Cite This Study

Joshi et al. (2015) studied this question.

synapsesocial.com/papers/6aa11c9efea20c06db8c9bc6 https://doi.org/10.2967/jnumed.114.153494

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Implication

Validation study demonstrates reliable amyloid plaque quantification in postmortem and healthy cohorts, highlighting an accurate MRI-free PET analysis method.

A Semiautomated Method for Quantification of F 18 Florbetapir PET Images

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Implication

Key Points

Cite This Study

A Semiautomated Method for Quantification of F 18 Florbetapir PET Images

Discussion

Member takes

Implication

Key Points

Cite This Study

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