Key result
Human and mouse skeletal muscle mitochondria lack LDH activity and cannot metabolize lactate.
Population
Human and mouse vastus lateralis muscle samples (100 mg)
Design
Preclinical
Authors
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Challenges mitochondrial lactate oxidation assumptions in skeletal muscle; hypothesis-generating for shuttling mechanisms and requires in vivo confirmation.
Skeletal muscle mitochondria are devoid of lactate dehydrogenase and are unable to metabolize lactate.
Rasmussen et al. (2002) studied this question. Skeletal muscle mitochondria from human and mouse vastus lateralis contain no lactate dehydrogenase activity (detection limit ~0.05%) and are unable to metabolize lactate.
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