Key result
IV treprostinil reduces pulmonary arterial pressures vs saline during surgery in children with severe PAH.
Why the study?
The study was designed to evaluate the effects of treprostinil injection on pulmonary blood pressure control in children with congenital heart disease complicated by severe pulmonary arterial hypertension.
Does treprostinil improve hemodynamic and pulmonary arterial pressure parameters in children with congenital heart disease complicated by severe pulmonary arterial hypertension during surgery?
RCT (n=80)
Randomly divided
No
Does treprostinil improve hemodynamic and pulmonary arterial pressure parameters in children with congenital heart disease complicated by severe pulmonary arterial hypertension during surgery?
p-value: p=<0.05
Intravenous treprostinil during surgery for congenital heart disease with severe PAH significantly reduces pulmonary arterial pressures and improves hemodynamics.
No takes yet. Share an insight, caveat, or question.
May warrant cautious consideration in pediatric CHD-PAH; leaves open need for larger confirmatory trials.
Jiang et al. (2021) conducted an RCT in Congenital heart disease complicated by severe pulmonary arterial hypertension (n=80). Treprostinil vs. Normal saline was evaluated on Pulmonary arterial pressure parameters (PASP, PADP and PAMP) after cardiopulmonary bypass (p=<0.05). Intravenous treprostinil during surgery for children with congenital heart disease and severe pulmonary arterial hypertension significantly reduced pulmonary arterial pressures compared to saline (P<0.05).
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