Key result
Prolonged refractory seizures trigger Takotsubo cardiomyopathy complicated by cardiogenic shock resolving with supportive care.
Why the study?
Takotsubo cardiomyopathy is a reversible yet underdiagnosed cause of ICU morbidity and mortality, with associations between central nervous system disorders such as epilepsy and TC being increasingly reported.
Case Report (n=1)
Prolonged refractory seizures can precipitate Takotsubo cardiomyopathy, highlighting the importance of cardiac evaluation in patients with severe CNS stress.
Refractory seizures may precipitate Takotsubo with shock; extends neurologic trigger spectrum but remains hypothesis-generating.
Takotsubo cardiomyopathy(TC) is a reversible, yet underdiagnosed cause of mortality and morbidity in the intensive care units. It occurs secondary to sudden catecholamine surge precipitated by any form of emotional or pathological stress. Association between central nervous system disorders and Takotsubo cardiomyopathy is being increasingly reported. Epilepsy is the second most common CNS disorder to trigger TC, SAH being the first. We report a case of TC in an elderly man with prolonged, recurrent seizure episodes refractory to the commonly used antiepileptic drugs (AEDs), who developed unexplained tachycardia, hypotension and elevated cardiac enzymes.
No takes yet. Share an insight, caveat, or question.
Khadka et al. (2021) conducted a case report in Takotsubo cardiomyopathy (n=1). Prolonged refractory seizure was evaluated on Clinical course of Takotsubo cardiomyopathy. Prolonged refractory seizures in a 69-year-old male triggered Takotsubo cardiomyopathy complicated by cardiogenic shock, which resolved with supportive care and antiepileptic therapy.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: