Key result
Preterm birth and maternal smoking were associated with a 3- to 4-fold greater rise in blood pressure during head-up tilt compared to term-born controls.
Why the study?
Does being born preterm or to a smoking mother increase cardiovascular stress reactivity in infants?
Population
78 infants, assessed at 40 to 42 weeks post-conception.
Comparison
Breathing 4% CO2 for 4 minutes or passive… vs Responses compared between…
Design
Cross-sectional
Authors
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May indicate early CV programming in affected infants; hypothesis-generating and requires longitudinal confirmation before clinical implications.
Observational (n=78)
Does being born preterm or to a smoking mother increase cardiovascular stress reactivity in infants?
Infants born preterm or to mothers who smoke exhibit heightened cardiovascular stress reactivity, suggesting early 'programming' of cardiovascular dysfunction.
Cohen et al. (2008) conducted an observational in Perinatal complications (preterm birth, maternal smoking) (n=78). Maternal smoking or preterm birth vs. Term-born babies to nonsmoking mothers was evaluated on Blood pressure and heart rate responses to breathing 4% CO2 for 4 minutes or to passive head-up tilt to 60 degrees. Preterm birth and maternal smoking were associated with a 3- to 4-fold greater rise in blood pressure during head-up tilt compared to term-born controls.
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