A patient with acute monoblastic leukemia developed a coagulopathy during chemotherapy. Coagulation studies showed thrombocytopenia, hypofibrinogenemia, high levels of fibrinogen degradation products, a negative protemine test but a normal antithrombin III level. These observations suggest that coagulation abnormalities appearing in acute leukemia are not necessarily due to diffuse intravascular coagulation.
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Vellenga et al. (2009) studied this question.
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