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June 17, 2026Acta Haematologica

Limited prognostic value of ELN classification and relevance of molecular ontogeny in acute myeloid leukemia post myeloproliferative neoplasms: a retrospective multicenter study

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Authors

ECEdmond ChicheInsermCFCaroline FileniSBSarah Bonnet

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Implication

Retrospective multicenter study finds limited prognostic value of ELN classification in AML post MPN, suggesting new trial designs.

Key Points

  • The aim is to assess the prognostic value of ELN classification in acute myeloid leukemia after myeloproliferative neoplasms and evaluate molecular factors affecting outcomes.
  • Retrospective analysis of data from 166 patients treated in France and the US.
  • Evaluation of treatment outcomes including intensive chemotherapy, hypomethylating agents, and allogeneic stem cell transplantation.
  • Use of next-generation sequencing data to analyze molecular mutations affecting prognosis.
  • Overall response rates were 57% for intensive chemotherapy, 20% for hypomethylating agents, and 25% for best supportive care.
  • Median overall survival was 7.2 months with allogeneic stem cell transplantation improving survival significantly to 6.7 months compared to 1.3 months without it (p<0.001).
  • JAK2 mutations were associated with worse survival outcomes (p=0.037), while spliceosome mutations predicted poor prognosis (p=0.015).

Cite This Study

Chiche et al. (2026) studied this question.

synapsesocial.com/papers/6a323c29d50b63ecad2066dahttps://doi.org/10.1159/000552809
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