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A new strategy to construct shell crosslinked nanoparticles has been developed, containing large numbers of effective DOTAlysines per particle (> 400) for 64Cu radiolabeling. These 64Cu-complexed nanoparticles show impressive specific activities (ca. 400 μCi μg–1), which suggests that they will serve as highly sensitive in vivo PET tracers at low administering doses.
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Sun et al. (2007) studied this question.
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