Key result
LCZ696 caused greater attenuation of the progression of proteinuria and reduced renal injury compared to valsartan alone or valsartan plus hydralazine in type 2 diabetic rats.
Why the study?
Does LCZ696 attenuate the progression of proteinuria and renal injury in type 2 diabetic rats compared to valsartan alone or valsartan plus hydralazine?
Does LCZ696 attenuate the progression of proteinuria and renal injury in type 2 diabetic rats compared to valsartan alone or valsartan plus hydralazine?
LCZ696 demonstrates a reno-protective effect by attenuating proteinuria and renal injury in a rat model of type 2 diabetes, suggesting potential benefits beyond standard ARB therapy.
Extends preclinical support for LCZ696 in diabetic proteinuria; leaves open human translation and should not change practice.
We examined the effects of the angiotensin receptor-neprilysin inhibitor LCZ696 on overt proteinuria and renal injury in type 2 diabetic Otsuka-Long- Evans-Tokushima-Fatty (OLETF) rats. Aged OLETF rats were also treated with either valsartan or valsartan plus hydralazine for comparison. LCZ696 caused greater attenuation of the progression of proteinuria than either valsartan alone or valsartan combined with hydralazine. Reduced glomerular injury and tubulointerstitial fibrosis were also observed in LCZ696-treated rats. Moreover, LCZ696 prevented increases in blood urea nitrogen (BUN) and creatinine levels. These data suggest that LCZ696 elicits a reno-protective effect against type 2 diabetes with overt proteinuria.
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Rahman et al. (2019) studied Type 2 diabetes with overt proteinuria. LCZ696 vs. Valsartan alone or valsartan plus hydralazine was evaluated on Progression of proteinuria. LCZ696 caused greater attenuation of the progression of proteinuria and reduced renal injury compared to valsartan alone or valsartan plus hydralazine in type 2 diabetic rats.
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