Palladium-catalyzed alkynylation of aryl and hetaryl halides has found wide application in the areas of synthetic, heterocyclic, and medicinal chemistry. Attempts to introduce the stable and potentially recyclable palladium/carbon has provided an attractive alternative to the homogeneous palladium catalytic process. The present article provides a personal account of the outcome of the use of conventional palladium catalysts versus palladium/carbon, especially under Sonogashira conditions.
No takes yet. Share an insight, caveat, or question.
Manojit Pal (2009) studied this question.