Reactivity control using a Schlenk line

Schlenk line (SL) techniques are very common for manipulating air and/or moisture sensitive compounds in organic, inorganic and bioorganic chemistry. Physical and chemical hazards such as pressure burst, explosions, and implosions are usually associated with the SL manipulations due to the use of inert gas, vacuum, liquid nitrogen and chemicals. Therefore researchers require skills in using the Schlenk line for chemical manipulations. This manuscript describes about the SL set-up, its use for controlling reactivity of hydrogenation and moisture sensitive chemicals, and the hazards associated with manipulations.