Key result
The RCAN1-calcineurin axis regulates myocardial damage during ischemia-reperfusion, providing the mechanism by which RCAN1 deletion exacerbates infarction in the heart and brain.
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Design
Editorial
This editorial discusses the underlying mechanism by which RCAN1 deletion exacerbates ischemia/reperfusion-induced infarction in the heart.
CAN1 (regulator of calcineurin 1) is an endogenous inhibitor of the Ca 2+ -activated protein phosphatase calcineurin.It has been known for some time that deletion of RCAN1 in the mouse exacerbates ischemia/reperfusioninduced infarction in heart 1 and brain. 2 In this issue of Circulation Research, Parra et al 3 elucidate an underlying mechanism.
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Corbalan et al. (2018) studied this question. The RCAN1-calcineurin axis regulates myocardial damage during ischemia-reperfusion, providing the mechanism by which RCAN1 deletion exacerbates infarction in the heart and brain.
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