Key result
General and visceral obesity are independently linked to graded increases in preclinical carotid IMT.
Cross-Sectional (n=1,458)
No
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Both general obesity (BMI) and visceral obesity (preperitoneal fat thickness) are independently and interactively associated with increased carotid intima-media thickness in middle-aged and older Japanese patients with a BMI ≥23 kg/m².
OBJECTIVE: The association between obesity and atherosclerotic disease is controversial. We examined whether common carotid intima-media thickness (IMT), a precursor to preclinical atherosclerosis, was associated with total body fatness or the accumulation of fat mass in the abdominal region in middle-aged and older persons. METHODS: Participants were consecutively enrolled from patients aged >or=50 years, and were 623 men aged 73+/-10 (mean+/-standard deviation) years and 835 women aged 76+/-10 years. Demographic data were collected and maximal preperitoneal fat thickness (PFT(max)) and carotid intima-media thickness (IMT) were evaluated on B-mode ultrasonography. Subjects were divided into 3 groups on the basis of body mass index (BMI), a marker of general obesity. RESULTS: It was shown by multiple regression analysis for IMT that age, smoking status, hypertension and uric acid were significantly associated with IMT in subjects in the lowest BMI group (<20 kg/m(2)), and age, hypertension, dyslipidemia and uric acid in middle BMI group (20-22.9 kg/m(2)). Moreover, man sex, age, BMI, PFT(max), smoking status, hypertension and uric acid were significantly associated with IMT in subjects with highest BMI group (>or=23 kg/m(2)). Analysis of covariance showed that interaction between BMI and visceral obesity (f=7.202, p=0.007) was significantly associated with IMT, in addition to age, visceral obesity, smoking status, hypertension, dyslipidemia and uric acid. CONCLUSION: The present study indicates a graded and independent association between general and visceral obesity and preclinical carotid artery changes in patients aged >or=50 years with a BMI >or=23 kg/m(2).
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Kawamoto et al. (2008) conducted a cross-sectional in Atherosclerosis risk in middle-aged and older persons (n=1,458). General obesity (BMI) and visceral fat accumulation vs. Normal BMI and no visceral obesity was evaluated on Common carotid intima-media thickness (IMT) (F=7.202, p=0.007). General and visceral obesity showed a graded and independent association with preclinical carotid artery changes, with a significant interaction between BMI and visceral obesity on IMT.
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