Key result
End-stage renal disease linked to higher CIMT and elevated oxidative stress versus controls.
Why the study?
Is carotid intima-media thickness increased in patients with end-stage renal disease compared to controls?
Observational (n=30)
Is carotid intima-media thickness increased in patients with end-stage renal disease compared to controls?
CIMT is elevated in ESRD patients prior to dialysis, suggesting its utility as a noninvasive marker for accelerated atherosclerosis in this population.
Accelerated atherosclerosis and cardiovascular disease are major causes of morbidity and mortality in patients of end-stage renal disease. Carotid intima media thickness is taken as a useful surrogate marker of atherosclerosis. Thirty end-stage renal disease (ESRD) patients were subjected to ultrasonography to study CIMT before the initiation of dialysis. CIMT was found to be higher in ESRD patients than in controls. Levels of a serum marker of oxidative stress were also found to be higher in patients than in the controls. CIMT is an easy, noninvasive, reproducible, and cost-effective investigation in patients with chronic renal failure.
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Kumar et al. (2009) conducted an observational in End-stage renal disease (n=30). End-stage renal disease vs. Controls was evaluated on Carotid intima media thickness (CIMT). End-stage renal disease was associated with higher carotid intima-media thickness and elevated serum markers of oxidative stress compared to controls.
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