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Contact dermatitis to Biobrane has not been reported previously. We report a patient who developed a bullous skin reaction directly related to a second exposure to Biobrane. The second exposure occurred 18 days after initial use of Biobrane, and the bullous reaction developed within 48 hours of repeat exposure. Sensitivity was confirmed by patch testing. Clinicians should be aware of the possibility of contact dermatitis to Biobrane.
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Reed et al. (1985) studied this question.
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