Key result
Preeclampsia is linked to ~300 differentially expressed circRNAs in placental tissue versus controls.
Population
75 placental tissue samples
Design
Case-control
Authors
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Differential circRNA expression in PE placentas may reflect pathogenesis; leaves open biomarker or therapeutic validation.
Case-Control (n=75)
p-value: p=<0.0001
Circular RNAs are differentially expressed in preeclampsia placental tissues and may contribute to its pathogenesis by acting as miRNA sponges.
Qian et al. (2016) conducted a case-control in Preeclampsia (n=75). Preeclampsia vs. Gestational age-matched premature birth controls was evaluated on Differential expression of circular RNAs in placental tissues (p=<0.0001). Preeclampsia was associated with significant differential expression of circular RNAs in placental tissues, including 143 up-regulated and 158 down-regulated circRNAs compared to controls.
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