The global HIV metabolome cannot be defined without Africa

This is the authors' abstract. We don't add key points for this paper.

Metabolomics has emerged as an important tool for characterising the metabolic pathways dysregulated by HIV-1 infection and long-term antiretroviral therapy.1 By capturing small molecules that reflect immune activation, chronic inflammation, metabolic dysfunction, and age-related comorbidities among people living with HIV (PLWH),2 metabolomics provides insights into disease biology. As metabolomics increasingly informs biomarker discovery and precision medicine, it is helping define the HIV-1 metabolome, providing a foundation for understanding HIV-1 disease mechanisms, identifying clinically relevant biomarkers, and improving disease monitoring and management.