Answers are grounded in this paper and cite their sources.
Blending in: A triazole-modified DNA duplex is perturbed in structure and dynamics, but this is delocalized over five base pairs. The conformation remains B-DNA and hydrogen bonds between the DNA phosphate oxygen and polymerases can be mimicked by the triazole nitrogen (see figure). The results explain the surprising biocompatibility of triazole-linked DNA.
No takes yet. Share an insight, caveat, or question.
Dallmann et al. (2011) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: