Key result
Diphenylalkylamine anti-anginals inhibit BTX-B binding in rat heart membranes, suggesting sodium channel interaction.
Population
Rat synaptosomal preparation and heart membrane preparation
Design
Preclinical
Authors
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Hypothesis-generating for sodium channel effects of anti-anginal arylalkylamines; leaves open translation to human therapeutics.
Anti-anginal arylalkylamines may exert their effects through interaction with sodium channels, as evidenced by their inhibition of [3H]-BTX-B binding in rat synaptosomal and heart membrane preparations.
Grima et al. (1986) studied this question. Anti-anginal arylalkylamines (Diphenylalkylamines) was evaluated on Inhibition of [3H]-BTX-B and [3H]-tetracaine binding. Diphenylalkylamines and structurally related anti-anginal drugs inhibited [3H]-BTX-B binding in rat synaptosomal and heart membrane preparations, suggesting interaction with the sodium channel.
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