Population
Rat heart membranes at different stages of development (fetal, newborn, adult) and cultured cardiac cells
Design
Preclinical
Authors
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Postnatal high-affinity TTX sites emerge in rat heart; leaves open whether similar maturation occurs in humans or affects arrhythmia risk.
This study provides the first direct demonstration of the coexistence of two families of TTX binding sites (high and low affinity) in rat heart plasma membranes, with high-affinity sites developing postnatally.
Renaud et al. (1983) studied this question.
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