Key result
Tetrodotoxin-resistant and tetrodotoxin-sensitive sodium channels in rat dorsal root ganglion neurons differed significantly in 50% inactivation voltage (-40 vs -70 mV) and activation kinetics (-15 vs -26 mV).
Population
Acutely dissociated dorsal root ganglion neurons isolated from 3-12-day-old and adult Sprague-Dawley rats
Comparison
Application of tetrodotoxin, saxitoxin… vs Control conditions
Design
Preclinical
Authors
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Subtype differences in rat DRG sodium channels warrant caution extrapolating to humans; leaves open targeted ion channel research in sensory and cardiovascular models.
TTX-S and TTX-R sodium channels in rat DRG neurons exhibit distinct biophysical properties, developmental expression profiles, and pharmacological sensitivities to neurotoxins, local anesthetics, and divalent cations.
Roy et al. (1992) studied None (healthy rat neurons). Tetrodotoxin, saxitoxin, lidocaine, and divalent cations vs. Control (toxin/drug-free solution) was evaluated on Sodium channel current activation/inactivation kinetics and pharmacological block (Kd values). Tetrodotoxin-resistant and tetrodotoxin-sensitive sodium channels in rat dorsal root ganglion neurons differed significantly in 50% inactivation voltage (-40 vs -70 mV) and activation kinetics (-15 vs -26 mV).
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