Key result
TTX-resistant sodium currents in adult rat dorsal root ganglion cells exhibited more depolarized activation and slower decay kinetics, but recovered from inactivation over ten times faster than TTX-sensitive currents.
Population
Small diameter dorsal root ganglion cells isolated from adult rats and maintained overnight in culture
Design
Preclinical
Authors
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Provides in vitro DRG INa characterization; leaves open in vivo roles and therapeutic relevance.
This study characterizes the distinct electrophysiological properties and kinetics of TTX-sensitive and TTX-resistant sodium currents in adult rat dorsal root ganglion cells.
Elliott et al. (1993) studied this question. Tetrodotoxin (TTX) was evaluated on Characteristics and kinetics of TTX-sensitive and TTX-resistant sodium currents. TTX-resistant sodium currents in adult rat dorsal root ganglion cells exhibited more depolarized activation and slower decay kinetics, but recovered from inactivation over ten times faster than TTX-sensitive currents.