Population
Single pacemaker cells isolated from rabbit sinoatrial node after 1-4 days in culture
Design
Preclinical
Authors
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Extends TTX-sensitive iNa characterization in rabbit SAN; hypothesis-generating for pacemaker mechanisms, requires human validation.
A TTX-sensitive Na+ current contributes significantly to the action potential upstroke in some rabbit sinoatrial node pacemaker cells, with characteristics similar to atrial and ventricular myocytes.
Muramatsu et al. (1996) studied this question.
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