Population
Single cells isolated from the sinus node region of rabbits (2 days old to adult)
Comparison
3 microM TTX and electrophysiological… vs Adult cells vs newborn cells, and baseline vs…
Design
Preclinical
Authors
Loading...
TTX-sensitive Na current supports automaticity in newborn rabbit SAN cells; hypothesis-generating for human developmental pacemaker mechanisms.
A TTX-sensitive inward sodium current plays a substantial role in the automaticity of newborn rabbit sino-atrial node cells, but its density and contribution decrease significantly with development.
Baruscotti et al. (1996) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: