Key result
Newborn rabbit sino-atrial node myocytes express a neuronal type I-like Na+ channel isoform with unusually high sensitivity to both TTX (half-maximal inhibition 26 +/- 5 nM) and Cd2+.
Population
Newborn rabbit sino-atrial node (SAN) myocytes and tissue
Comparison
Electrophysiological characterization using… vs Adult SAN tissue (for in situ hybridization)
Design
Preclinical
Authors
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May inform developmental models of SAN Na+ channel expression; leaves open relevance to human neonatal arrhythmias.
Newborn rabbit sino-atrial node myocytes express a neuronal type I-like Na+ channel isoform, which accounts for their unusually high sensitivity to both TTX and Cd2+.
Baruscotti et al. (1997) studied this question. Tetrodotoxin and Cadmium was evaluated on Na+ channel characteristics and mRNA expression. Newborn rabbit sino-atrial node myocytes express a neuronal type I-like Na+ channel isoform with unusually high sensitivity to both TTX (half-maximal inhibition 26 +/- 5 nM) and Cd2+.
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