Key result
Voltage clamp analysis of rabbit sinoatrial node cells revealed two distinct pacemaker cell types: Type I with only slow inward current, and Type II with both fast transient and slow inward currents.
Population
Single pacemaker cells isolated from the rabbit sinoatrial node and maintained in vitro for 1-3 days
Design
Preclinical
Authors
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No iNa in dominant SAN cells; leaves open its role in pacemaking and requires intact-tissue validation.
The study identifies two electrophysiologically distinct types of pacemaker cells in the rabbit sinoatrial node, clarifying the differential presence of the fast transient inward sodium current in dominant versus subsidiary pacemakers.
Richard D. Nathan (1986) studied this question. Voltage clamp analysis was evaluated on Electrophysiological behavior and inward currents. Voltage clamp analysis of rabbit sinoatrial node cells revealed two distinct pacemaker cell types: Type I with only slow inward current, and Type II with both fast transient and slow inward currents.
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