July 15, 2004ViewOpen Access

Requirement of neuronal‐ and cardiac‐type sodium channels for murine sinoatrial node pacemaking

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Population

Mouse sinoatrial (SA) node pacemaker cells and intact SA node preparations

Design

Preclinical

Authors

MLMing LeiWestern University SJSandra A. JonesHull York Medical School JLJie LiuHebei Medical University

Discussion

Member takes

Implication

Does not inform clinical sodium channel blocker use; leaves open Nav isoform roles in human SA node function.

Structured PICO

Population

Mouse sinoatrial (SA) node pacemaker cells and intact SA node preparations

Intervention

Tetrodotoxin (TTX) at nanomolar (10 or 100 nM) and micromolar (1-30 µM) concentrations

Outcome

Na+ currents (TTX-resistant and TTX-sensitive), pacemaking rate, and SA node conductionsurrogate

Both neuronal (TTX-sensitive, putative Nav1.1) and cardiac (TTX-resistant, Nav1.5) sodium channel isoforms are involved in murine SA node pacemaking, with Nav1.5 also required for action potential propagation to atrial muscle.

Cite This Study

Lei et al. (2004) studied this question.

synapsesocial.com/papers/6a6fbd635d37378ac1dccd6f https://doi.org/10.1113/jphysiol.2004.068643

View Full Paper

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Requirement of neuronal‐ and cardiac‐type sodium channels for murine sinoatrial node pacemaking

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Requirement of neuronal‐ and cardiac‐type sodium channels for murine sinoatrial node pacemaking

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider