Population
Rat ventricular myocytes (control and detubulated)
Comparison
200 nmol/L tetrodotoxin to selectively block… vs Control (no TTX)
Design
Preclinical
Authors
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TTX-sensitive Na channels dispensable for EC coupling in rat myocytes; leaves open their role in human HF or arrhythmias.
Neuronal TTX-sensitive sodium channels are concentrated at the t-tubules in rat ventricular myocytes but are not required for normal excitation-contraction coupling.
Brette et al. (2006) studied this question.
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