Population
Various cell types in culture including N1E 115 neuroblastoma, CCl 39 fibroblasts, embryonic chick…
Design
Preclinical
Authors
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No immediate clinical implications from animal cells; leaves open whether high- and low-affinity Na+ channel subtypes exist or matter in humans.
This study demonstrates the existence of distinct high- and low-affinity tetrodotoxin binding sites on voltage-sensitive Na+ channels across different excitable and non-excitable cell types.
Lombet et al. (1982) studied this question.
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