Characterization, solubilization, affinity labeling and purification of the cardiac Na+ channel using Tityus toxin gamma

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Population

Chick heart sarcolemma membrane

Design

Preclinical

Authors

Discussion

Provides initial biochemical evidence for cardiac Na channel structure; leaves open relevance to human electrophysiology and therapy.

Population

Chick heart sarcolemma membrane

Intervention

Tityus toxin gamma (TiTx gamma) from Tityus serrulatus scorpion venom

Outcome

Binding capacity, equilibrium dissociation constant, and purification of the cardiac Na+ channel

The cardiac Na+ channel from chick heart was purified and identified as a single large polypeptide of 230-270 kDa.

Lombet et al. (1984) studied this question.

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