March 1, 1989Journal of Biological ChemistryOpen Access

Isolation of Membranes Enriched in “Tetrodotoxin-insensitive” Saxitoxin-binding Sites from Mammalian Ventricle

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Population

Mammalian (sheep) ventricle

Design

Preclinical

Authors

DDDonald D. DoyleUniversity of Illinois Urbana-Champaign AWAnja WinterInstitute of Structural and Molecular Biology

Discussion

Member takes

Implication

Enables further characterization of myocardial sodium currents in animal models; leaves open translation to human disease.

Structured PICO

Population

Mammalian (sheep) ventricle

Intervention

Isolation of t-tubular sarcolemmal vesicles and solubilization by 1% digitonin

Outcome

Concentration and yield of tetrodotoxin-insensitive saxitoxin-binding sites (TIC)

The study successfully isolated and solubilized tetrodotoxin-insensitive sodium channels from mammalian ventricles, enabling further characterization of myocardial sodium currents.

Cite This Study

Doyle et al. (1989) studied this question.

synapsesocial.com/papers/6a910aa231a95240343e8e32 https://doi.org/10.1016/s0021-9258(19)84922-0

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Isolation of Membranes Enriched in “Tetrodotoxin-insensitive” Saxitoxin-binding Sites from Mammalian Ventricle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Isolation of Membranes Enriched in “Tetrodotoxin-insensitive” Saxitoxin-binding Sites from Mammalian Ventricle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider