Key result
Obese Zucker rats exhibit lower A2AR and higher A3R cardiac expression versus lean controls.
Why the study?
Does the adenosine receptor transcriptomic profile differ in cardiac tissue of obese Zucker rats compared to lean controls during fasting and acute hyperglycemia?
Does the adenosine receptor transcriptomic profile differ in cardiac tissue of obese Zucker rats compared to lean controls during fasting and acute hyperglycemia?
Obese Zucker rats exhibit altered adenosine receptor transcriptomic profiles in cardiac tissue, suggesting a potential pharmacological target in obesity-related cardiac changes.
AR and cytokine profiles in obese rat hearts during hyperglycemia remain hypothesis-generating; human studies required before any clinical consideration.
To evaluate the possible variations of adenosine receptor (AR) profile together with TNF-α and IL-6 mRNA in cardiac tissue of obese Zucker rats (OZR) during fasting conditions (fc) and during the induction of acute hyperglycemia (AH). OZR (O, n=21) and age-matched lean control rats (CO, n=18) were studied during fc (COfc, n=8; Ofc, n=13) and during the induction of AH (COAH, n=10; OAH, n=8). The histopathologic analysis performed on O and CO heart samples did not show abnormalities of myocardial structure. The AR transcriptomic profile was analyzed in O and CO by real-time polymerase chain reaction (PCR) and a significantly lower mRNA expression was observed for A2AR in O with respect to CO (p=0.047), while a significant upregulation was observed for A3R in O with respect to CO (p=0.002). No significant differences between O and CO were observed for TNF-α or IL-6. Correlations were found between glycemia and A1R (p=0.03) and A2BR (p=0.002); total cholesterol and A2BR (p=0.02) and A3R (p=0.0002), as well as between IL-6 and A1R (p=0.05) and TNF-α and A2AR (p<0.0001). The modulation of ARs in these settings could represent a promising approach to pharmacological treatment, which must be supported by diet restrictions and physical exercise.
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Cabiati et al. (2015) studied Obesity and acute hyperglycemia (n=39). Obesity (Zucker rat model) vs. Age-matched lean control rats was evaluated on A2AR and A3R mRNA expression (p=0.047). Obese Zucker rats exhibited significantly lower A2AR mRNA expression (p=0.047) and higher A3R expression (p=0.002) in cardiac tissue compared to lean controls.
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