Key result
Induction of metabolic syndrome via a 50-week high-fat diet in Ossabaw swine significantly reduced cardiac β(1)- and β(2)-adrenoceptor protein expression compared to lean controls.
Why the study?
Does induction of metabolic syndrome via chronic high-fat feeding alter cardiac β(1)- and β(2)-adrenoceptor expression in an Ossabaw swine model?
Population
Ossabaw swine model (control lean and chronically high-fat-fed obese animals)
Comparison
Chronic high-fat feeding for 50 weeks to induce… vs Control lean diet
Design
Preclinical
Follow-up
50 weeks
Authors
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Should not yet inform clinical practice; leaves open whether β-adrenoceptor downregulation contributes to cardiac dysfunction in human metabolic syndrome.
Does induction of metabolic syndrome via chronic high-fat feeding alter cardiac β(1)- and β(2)-adrenoceptor expression in an Ossabaw swine model?
Induction of metabolic syndrome in a large animal model is accompanied by a significant reduction in cardiac β(1)- and β(2)-adrenoceptor protein expression, which may contribute to impaired cardiac function.
Ü. Deniz Dinçer (2011) studied Metabolic syndrome. High-fat diet vs. Control lean diet was evaluated on Cardiac β(1)- and β(2)-adrenoceptor protein expression. Induction of metabolic syndrome via a 50-week high-fat diet in Ossabaw swine significantly reduced cardiac β(1)- and β(2)-adrenoceptor protein expression compared to lean controls.