What is the clinical evidence from this study?

Study design: Other. Population: Metabolic Syndrome. Intervention: Western diet (WesD) vs. Regular chow (Ctrl). Primary outcome: Cardiac performance (ejection fraction, isovolumic relaxation time, fractional cell shortening).

October 10, 2025Circulation Research

Abstract Wed097: Metabolic Syndrome in Rodents Activates β-adrenergic Receptor Signaling Concealing Defects in Cardiac Performance

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Key result

Diet-induced metabolic syndrome masks underlying cardiac dysfunction via beta-adrenergic signaling in preclinical models.

Population

C57Bl/6 wild-type mice and β1- and β2-AR knockout (βAR-KO) mice

Comparison

Western diet for >4 months to induce Metabolic… vs Regular chow (Ctrl)

Design

Preclinical

Follow-up

>4 months

Authors

GPGiulia PiccininiUniversity of Parma DCDaniel O. CervantesNew York Medical College MSMichael SunSUNY Upstate Medical University

Discussion

Member takes

Implication

Metabolic syndrome induces compensatory β-adrenergic receptor activation in the heart, which masks underlying defects in cardiac and cardiomyocyte function.

Key Points

Metabolic syndrome exacerbates heart rate variations, indicating sympathoexcitation in the heart.
Inhibition of β-adrenergic receptors normalizes heart rates in mice with metabolic syndrome.
Echocardiographic analysis shows no baseline differences in cardiac function until β-AR blockade.
Left ventricular myocytes from metabolic syndrome mice exhibit increased cell shortening, revealing hidden cardiac dysfunction.

Structured PICO

Population

Male and female C57Bl/6 and βAR-KO mice subjected to chronic Western diet (>4 months) to induce metabolic syndrome.

Intervention

Western diet (WesD) for >4 months to induce Metabolic Syndrome, with or without acute β-adrenergic receptor blockade using propranolol

Comparator

Regular chow (Ctrl)

Outcome

Cardiac function (ejection fraction, isovolumic relaxation time) and cardiomyocyte function (fractional cell shortening, relaxation kinetics)surrogate

Metabolic syndrome induces compensatory β-adrenergic receptor activation in the heart, which masks underlying defects in cardiac and cardiomyocyte function.

Cite This Study

Piccinini et al. (2025) studied Metabolic Syndrome. Western diet (WesD) vs. Regular chow (Ctrl) was evaluated on Cardiac performance (ejection fraction, isovolumic relaxation time, fractional cell shortening). In mice, metabolic syndrome induced by a Western diet activated β-adrenergic receptor signaling, concealing underlying defects in cardiac function such as reduced ejection fraction.

synapsesocial.com/papers/68e861a57ef2f04ca37e47b9 https://doi.org/10.1161/res.137.suppl_1.wed097

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October 10, 2025Circulation Research

Abstract Wed097: Metabolic Syndrome in Rodents Activates β-adrenergic Receptor Signaling Concealing Defects in Cardiac Performance

View Full Paper

Ask AI

Bookmark

Key result

Diet-induced metabolic syndrome masks underlying cardiac dysfunction via beta-adrenergic signaling in preclinical models.

Population

C57Bl/6 wild-type mice and β1- and β2-AR knockout (βAR-KO) mice

Comparison

Western diet for >4 months to induce Metabolic… vs Regular chow (Ctrl)

Design

Preclinical

Follow-up

>4 months

Authors

GPGiulia PiccininiUniversity of Parma DCDaniel O. CervantesNew York Medical College MSMichael SunSUNY Upstate Medical University

Discussion

Member takes

Implication

Metabolic syndrome induces compensatory β-adrenergic receptor activation in the heart, which masks underlying defects in cardiac and cardiomyocyte function.

Key Points

Metabolic syndrome exacerbates heart rate variations, indicating sympathoexcitation in the heart.
Inhibition of β-adrenergic receptors normalizes heart rates in mice with metabolic syndrome.
Echocardiographic analysis shows no baseline differences in cardiac function until β-AR blockade.
Left ventricular myocytes from metabolic syndrome mice exhibit increased cell shortening, revealing hidden cardiac dysfunction.

Structured PICO

Population

Male and female C57Bl/6 and βAR-KO mice subjected to chronic Western diet (>4 months) to induce metabolic syndrome.

Intervention

Western diet (WesD) for >4 months to induce Metabolic Syndrome, with or without acute β-adrenergic receptor blockade using propranolol

Comparator

Regular chow (Ctrl)

Outcome

Cardiac function (ejection fraction, isovolumic relaxation time) and cardiomyocyte function (fractional cell shortening, relaxation kinetics)surrogate

Metabolic syndrome induces compensatory β-adrenergic receptor activation in the heart, which masks underlying defects in cardiac and cardiomyocyte function.

Cite This Study

synapsesocial.com/papers/68e861a57ef2f04ca37e47b9 https://doi.org/10.1161/res.137.suppl_1.wed097

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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