Key result
Western diet-induced metabolic syndrome in mice reduces HRV, reflecting sympathoexcitation and parasympathetic withdrawal.
Why the study?
Metabolic syndrome manifests reduced heart rate variability, but factors underlying the process remain to be fully elucidated.
Does Western diet-induced metabolic syndrome alter R-R interval properties and the brain-heart axis in mice?
Population
Male and female mice
Comparison
Western diet feeding vs regular chow
Design
Animal experimental study
Authors
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Highlights autonomic imbalance in diet-induced metabolic syndrome; leaves open translation to human arrhythmia risk.
Does Western diet-induced metabolic syndrome alter R-R interval properties and the brain-heart axis in mice?
Metabolic syndrome induced by a Western diet alters heart rate dynamics in mice through sympathoexcitation and parasympathetic withdrawal.
Meste et al. (2025) studied Metabolic syndrome. Western diet feeding vs. Regular chow was evaluated on Distribution and span of R-R intervals (sortRR and sortRRdev). Western diet-induced metabolic syndrome in mice resulted in shorter R-R intervals and reduced heart rate variability, reflecting sympathoexcitation and parasympathetic withdrawal.
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